Isotope ratio mass spectrometry (IRMS) is used to measure the ratio of elemental isotopes e.g. C12/C13, O16/O18, N14/N15, etc. The mass analyser is usually a magnetic sector, resulting in high sensitivity. In the measurement of carbon for example, the sample is converted to carbon dioxide, and the ratio of C12O2 (m/z 48) is compared against C13O2 (m/z 49). When hyphenated with a GC, the isotope ratios of individual analytes, rather than the whole sample, can be determined.

Isotope ratio mass spectrometry (IRMS) Training Courses

Classroom-based training courses: