1-day Hands-on Liquid-Liquid Extraction (LLE)

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Course summary

Course approval

Royal Society of Chemistry approved training logo

This course has been approved by the Royal Society of Chemistry for purposes of Continuing Professional Development (CPD).

Liquid-Liquid Extraction (LLE) is a method for separating compounds based on their relative solubilities in two different immiscible liquids, usually water (polar) and an organic solvent (non-polar). There is a net transfer of one or more species from one liquid into another liquid phase, generally from aqueous to organic. The solvent that is enriched in solute(s) is called the extract. LLE is a basic technique in chemical laboratories, where it is performed on large volumes via separating funnels and small volumes via vials. The technique can be miniaturised with XYZ autosamplers. The term partitioning is commonly used to refer to the underlying chemical and physical processes involved in LLE.

What will you learn on this course?

This course covers all the practical theory of solvent extraction, partitioning, solubility, miscibility, sample preparation, matrix modification including pH adjustment and the choice of relevant apparatus.

Learning outcomes

  • You will gain practical hands-on experience of modern Liquid-Liquid Extraction (LLE)
  • You will gain knowledge about transferring one or more compounds from one liquid into another, generally from aqueous into organic
  • You will learn real world applications
  • You will learn which apparatus is required for efficient partitioning

Who is this course for?

This course requires good knowledge of GC (or GC-MS) or HPLC (or LC-MS).

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